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Updated: Oct 29, 2025
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
Imaging Early Response to Checkpoint Inhibition
Quinlan Cullen1,2,3, Kayvan R Keshari4,2,3
1Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
Immune checkpoint blockade therapy has achieved remarkable clinical success, but these promising results have been limited to a minority of patients. Thus far, efforts to establish a predictive biomarker or accurately assess early response to treatment have been fruitless. In this issue of Cancer Research, Saida and colleagues utilized advanced molecular imaging modalities to assess changes in the tumor microenvironment that correlate with tumor response to immune checkpoint blockade therapy in vivo This study suggests a combination of imaging biomarkers with potential for delineating clinical response to immunotherapy.See related article by Saida et al., p. 3693.
Insights
Predicting response to immune checkpoint blockade therapy remains challenging. This study used advanced molecular imaging to identify changes in the tumor microenvironment, suggesting new biomarkers for assessing immunotherapy effectiveness in cancer patients.
Area of Science:
- Oncology
- Immunology
- Medical Imaging
Background:
- Immune checkpoint blockade (ICB) therapy offers significant clinical benefits but benefits only a subset of patients.
- Predictive biomarkers for ICB therapy and early response assessment are currently lacking.
- Understanding tumor microenvironment dynamics is crucial for improving ICB efficacy.
Purpose of the Study:
- To investigate advanced molecular imaging techniques for assessing tumor microenvironment changes.
- To correlate imaging-detected changes with tumor response to ICB therapy in vivo.
- To identify potential imaging biomarkers for predicting clinical response to immunotherapy.
Main Methods:
- Utilized advanced molecular imaging modalities to monitor the tumor microenvironment.
- Assessed dynamic changes within the tumor microenvironment during ICB therapy.
- Correlated imaging findings with established measures of tumor response.
Main Results:
- Identified specific changes in the tumor microenvironment detectable by molecular imaging.
- Demonstrated a correlation between these imaging biomarkers and tumor response to ICB therapy.
- Showcased the potential of a combination of imaging biomarkers for response assessment.
Conclusions:
- Advanced molecular imaging can reveal critical changes in the tumor microenvironment.
- These imaging biomarkers show promise for predicting response to immune checkpoint blockade.
- This approach may aid in delineating clinical response and guiding immunotherapy strategies.
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