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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.5K

Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and

Sultana Shajahan1,2, Janaki Amin2, Jacqueline K Phillips1

  • 1Department of Biomedical Science, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.

Plos One
|July 12, 2021
PubMed

Insights

Men with chronic kidney disease (CKD) face a slightly higher risk of cardiovascular death compared to women. This study analyzed data from 48 studies, emphasizing the need for risk awareness in both sexes.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is a major health issue linked to increased cardiovascular mortality.
  • Historically, men have had higher cardiovascular mortality than women in the general population.
  • Emerging evidence suggests similar or higher cardiovascular risk in women with CKD.

Purpose of the Study:

  • To systematically review and meta-analyze existing literature on sex differences in cardiovascular mortality among CKD patients.
  • To clarify inconsistent findings regarding cardiovascular mortality risk between men and women with CKD.

Main Methods:

  • A systematic review and meta-analysis of studies published from January 2004 to October 2020.
  • Searches conducted across PubMed/Medline, EMBASE, Scopus, and Cochrane databases.
  • Inclusion of 48 studies reporting cardiovascular mortality risk estimates (RE) with 95% confidence intervals (CI) for adult men versus women with CKD.

Main Results:

  • Meta-analysis revealed that male sex is associated with elevated cardiovascular mortality in CKD patients (RE 1.13, CI 1.03-1.25).
  • Subgroup analyses indicated higher risk in men in studies from the USA and in both haemodialysis and non-dialysis-dependent CKD populations.
  • The overall increased risk for men was marginal, highlighting the need for risk awareness in both sexes.

Conclusions:

  • While men with CKD exhibit a slightly higher cardiovascular mortality risk, the difference is marginal.
  • Both men and women with CKD require appropriate cardiovascular risk awareness and management.
  • Further research is warranted to explore how treatment modality and geographic factors influence sex-based differences in CKD cardiovascular mortality.

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