Decision aids for female BRCA mutation carriers: a scoping review protocol
Sarah A McGarrigle1, Geraldine Prizeman2, Carol Spillane3
1Faculty of Health Sciences, Trinity College Dublin, Dublin, Ireland.
BMJ Open
|July 13, 2021
Summary
This review maps evidence on decision aids for women with BRCA mutations, aiming to improve risk management choices for hereditary breast and ovarian cancer. It identifies features of existing aids to support women making complex health decisions.
Area of Science:
- Genetics and Oncology
- Decision Science
- Public Health
Background:
- Women with pathogenic mutations in Breast Cancer Susceptibility Genes 1 or 2 (BRCA1 or BRCA2) face significantly higher risks of breast and ovarian cancers.
- Effective cancer risk management strategies are available, but decision-making for these women is complex and multifactorial.
- A gap exists in understanding patient decision aids tailored for BRCA mutation carriers without a personal cancer history.
Purpose of the Study:
- To conduct a scoping review mapping the evidence on cancer risk management decision-making among BRCA mutation carriers without a personal history of cancer.
- To identify and describe the characteristics of patient decision aids developed for this specific population.
- To inform the design and adaptation of decision aids to better support women with hereditary cancer risk.
Main Methods:
- The review will follow the Joanna Briggs Institute's scoping review methodology and the PRISMA extension for Scoping Reviews checklist.
- A comprehensive search of five electronic databases (MEDLINE, EMBASE, Cochrane Library, CINAHL, Web of Science) will be performed with no date or language restrictions.
- Data extraction will be conducted by two independent reviewers using a predefined form, with findings presented narratively and in tabular form.
Main Results:
- The review will identify and characterize existing patient decision aids for BRCA mutation carriers.
- Evidence on the features and usability of these decision aids will be synthesized.
- The findings will highlight areas for improvement and development of new decision support tools.
Conclusions:
- This scoping review will provide a comprehensive overview of decision aids available for BRCA mutation carriers at high risk for breast and ovarian cancer.
- The findings will be valuable for healthcare providers and researchers in developing and implementing effective decision support strategies.
- Enhanced decision aids can empower women with BRCA mutations to make informed choices regarding cancer risk management.
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