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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Single Dynamic Covalent Bond Tailored Responsive Molecular Junctions.

Yong Hu1,2, Jin Li1, Yu Zhou1

  • 1State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.

Angewandte Chemie (International Ed. in English)
|July 13, 2021
PubMed
Summary
This summary is machine-generated.

Researchers created responsive molecular devices using dynamic covalent bonds. These devices show tunable electrical states, paving the way for advanced molecular electronics.

Keywords:
STM break-junction techniqueacyl hydrazone bonddynamic covalent chemistrymolecular junctionresponsive molecular device

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Area of Science:

  • Molecular electronics
  • Materials science
  • Supramolecular chemistry

Background:

  • Dynamic covalent bonds (DCBs) are crucial for fabricating responsive molecular devices.
  • Tailored molecular devices are essential for advancements in molecular electronics.

Purpose of the Study:

  • To fabricate and characterize molecular devices using a single dynamic acyl hydrazone bond.
  • To investigate the responsive properties and conductance states of these molecular devices.

Main Methods:

  • Scanning tunneling microscopy break-junction (STM-BJ) technique
  • Eutectic gallium-indium (EGaIn) liquid metal electrodes
  • Density functional theory (DFT) calculations

Main Results:

  • Single dynamic acyl hydrazone bond-tailored molecular devices exhibited acid-base and photo-thermal responses.
  • Three well-defined molecular conductance states were observed with reversible switching.
  • ON/OFF ratios of ≈10 for single-molecule junctions and ≈3 for SAMs-based junctions were achieved.

Conclusions:

  • The observed multiple conductance states result from dynamic acyl hydrazone bond exchange and C=N isomerization.
  • This study demonstrates a pathway for designing tailored single-molecule electrical devices by incorporating DCBs.
  • The findings open new avenues for developing responsive molecular electronic components.