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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Diagnosing giant cell arteritis: a comprehensive practical guide for the practicing rheumatologist.
Peter M Andel1,2, Stavros Chrysidis3, Julia Geiger4
1Department of Cardiology, Østfold Hospital Trust, Grålum.
Giant cell arteritis (GCA) diagnosis is improved by fast-track clinics and ultrasound. This review offers a simple diagnostic algorithm for rheumatologists lacking advanced imaging expertise.
Area of Science:
- Rheumatology
- Internal Medicine
- Vascular Medicine
Background:
- Giant cell arteritis (GCA) is the most prevalent large vessel vasculitis in older adults.
- Advanced imaging techniques have significantly impacted GCA diagnosis.
- The fast-track clinic model, integrating ultrasound, enables rapid and accurate GCA diagnosis and treatment.
Purpose of the Study:
- To review current evidence on diagnosing GCA.
- To propose a simplified diagnostic algorithm for GCA.
- To support rheumatologists outside specialist centers in diagnosing GCA.
Main Methods:
- Review of current literature on GCA diagnostic modalities.
- Development of a straightforward diagnostic algorithm for GCA.
- Focus on ultrasound (US) as a key diagnostic tool.
Main Results:
- Fast-track clinics with US improve GCA prognosis and are cost-effective.
- Diagnostic accuracy of imaging modalities is operator-dependent.
- A need exists for accessible diagnostic tools in non-specialist settings.
Conclusions:
- A simple GCA diagnostic algorithm can aid rheumatologists in resource-limited settings.
- Integrating ultrasound into fast-track clinics is effective for GCA diagnosis.
- Standardizing diagnostic approaches can improve patient outcomes for GCA.
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