Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

503
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
503
Modeling in Therapy01:26

Modeling in Therapy

198
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
198

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal E-Cigarette Exposure Reprograms the Cardiac Proteome and Increases Ischemia Susceptibility in a Sex-Dependent Manner.

Biology of reproduction·2026
Same author

Blocking interaction of sclerostin loop3 with osteoblastic LRP4 counteracts bone loss without increasing arterial stiffness during mechanical unloading.

Journal of orthopaedic translation·2026
Same author

COVID vaccination and economic game decisions: The role of analytical thinking.

Human vaccines & immunotherapeutics·2026
Same author

Distinct neural signatures of reward processing underlying bipolar disorder and major depressive disorder: a systematic review and meta-analysis.

Psychiatry research. Neuroimaging·2026
Same author

A CRISPR/Cas9-regulated dual-ring topological allosteric probe for detection of the EGFR L858R resistance mutation in CTCs.

Analytical methods : advancing methods and applications·2026
Same author

Human frontopolar cortex plays a causal role in decomposing high-dimensional information during decision making.

NeuroImage·2026
Same journal

Language network functional connectivity varies by aphasia type and severity.

NeuroImage. Clinical·2026
Same journal

Within-subject alterations in CSF and blood flow dynamics following rhythm-control intervention in atrial fibrillation: An exploratory multimodal MRI study.

NeuroImage. Clinical·2026
Same journal

Diffusion MRI of white matter alterations in chronic traumatic brain injury: a systematic review and meta-analysis.

NeuroImage. Clinical·2026
Same journal

Decoding functional changes in the brain following ischemic stroke: a multimodal feature approach integrating fNIRS with machine learning and deep learning.

NeuroImage. Clinical·2026
Same journal

Structural brain alterations in chronic primary pain: a multimodal MRI study.

NeuroImage. Clinical·2026
Same journal

Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: A pilot study.

NeuroImage. Clinical·2026
See all related articles

Related Experiment Video

Updated: Oct 29, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.9K

Mapping working memory-specific dysfunction using a transdiagnostic approach.

Zachary Adam Yaple1, Serenella Tolomeo2, Rongjun Yu3

  • 1Department of Psychology, York University, Toronto, Canada.

Neuroimage. Clinical
|July 13, 2021
PubMed
Summary
This summary is machine-generated.

Working memory (WM) deficits are common in schizophrenia and mood disorders. Brain imaging reveals shared neural circuit abnormalities in these conditions, suggesting common functional impairments.

Keywords:
Bipolar disorderMajor depressive disorderSchizophreniaWorking memory

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.4K
A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury
05:53

A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury

Published on: May 7, 2021

3.5K

Related Experiment Videos

Last Updated: Oct 29, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.9K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.4K
A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury
05:53

A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury

Published on: May 7, 2021

3.5K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Working memory (WM) is crucial for executive function.
  • Schizophrenia and mood disorders share genetic and clinical traits.
  • WM is a potential endophenotype for these disorders, but neural circuitry overlap is unclear.

Purpose of the Study:

  • To investigate shared neural circuitry in working memory across psychiatric disorders.
  • To analyze functional brain activity during n-back tasks in schizophrenia, bipolar disorder, and major depressive disorder.

Main Methods:

  • Coordinate-based meta-analysis of 34 BOLD-fMRI studies.
  • Focused on the n-back task to measure WM capacity (maintenance, updating, interference control).
  • Compared brain activity between psychiatric patients and healthy controls.

Main Results:

  • All patient groups exhibited reduced activity in the striatum, anterior insula, and frontal lobe.
  • Compromised neural networks related to WM were observed across schizophrenia, major depressive disorder, and bipolar disorder.

Conclusions:

  • Findings support common functional abnormalities in WM across schizophrenia and mood disorders.
  • Shared neural circuitry underlies working memory deficits in these severe psychiatric conditions.