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Updated: Oct 29, 2025
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
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Is glucose the scapegoat for tumor evasion?
Lydia N Raines1, Stanley Ching-Cheng Huang2
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Cancer Cell
|July 14, 2021
Summary
Tumor-infiltrating myeloid cells consume more glucose than tumor cells. However, tumor cells remain the primary consumers of glutamine in the tumor microenvironment, impacting cancer metabolism.
Area of Science:
- Oncology
- Cancer Metabolism
- Immunology
Background:
- Tumor cells exhibit high aerobic glycolysis for energy.
- The metabolic interplay within the tumor microenvironment is complex.
- Glucose and glutamine are key nutrients for cancer cells.
Purpose of the Study:
- To investigate glucose and glutamine utilization by tumor cells and tumor-infiltrating myeloid cells.
- To understand the metabolic roles of different cell types in the tumor microenvironment.
Main Methods:
- Metabolic flux analysis
- Isotope tracing
- Flow cytometry
Main Results:
- Tumor-infiltrating myeloid cells show a higher capacity for glucose uptake compared to tumor cells.
- Myeloid cells consume substantial amounts of glucose within the tumor.
- Tumor cells exhibit the highest glutamine utilization in the tumor microenvironment.
Conclusions:
- Myeloid cell glucose uptake is significant in the tumor microenvironment.
- Tumor cell glutamine utilization is a critical metabolic feature.
- Differential nutrient utilization impacts cancer progression and immune responses.
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