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Updated: Oct 29, 2025

Designing a Bio-responsive Robot from DNA Origami

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

DNA Assembly-Based Stimuli-Responsive Systems.

Shasha Lu¹, Jianlei Shen¹, Chunhai Fan^1,2

¹School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Institute of Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|July 14, 2021

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Dynamic DNA nanotechnology utilizes stimuli-responsive systems for remote control of DNA nanostructures. This review covers response mechanisms and applications in nanofabrication and biomedical research, highlighting future opportunities.

Area of Science:

Biotechnology
Materials Science
Nanotechnology

Background:

Static DNA nanostructures face limitations in control and reversibility.
Dynamic DNA nanotechnology offers enhanced control through stimuli-responsive designs.
Integration of organic molecules, polymers, and chemical reactions expands applications.

Purpose of the Study:

To review DNA assembly-based stimuli-responsive systems.
To focus on response units and mechanisms triggered by various exogenous stimuli.
To discuss applications in nanofabrication and biomedical research.

Main Methods:

Review of literature on stimuli-responsive DNA assembly.
Analysis of response units and mechanisms for diverse stimuli (pH, light, temperature, ions, etc.).

Keywords:

biomedical applications dynamic DNA nanotechnology nanofabrication stimuli‐responsive systems

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Last Updated: Oct 29, 2025

Designing a Bio-responsive Robot from DNA Origami

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Published on: July 8, 2013

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Categorization of applications in nanofabrication and biomedical fields.

Main Results:

Detailed overview of DNA nanostructures responding to exogenous stimuli.
Exploration of applications including DNA architectures, nanomachines, biosensing, and therapeutics.
Identification of key response mechanisms and design principles.

Conclusions:

Stimuli-responsive DNA systems offer remote and reversible control, overcoming static nanostructure limitations.
Broad applications in nanofabrication and biomedicine are enabled by these dynamic systems.
Opportunities and challenges in advancing DNA assembly-based stimuli-responsive systems are identified.