Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 3, 2026

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
08:29

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation

Published on: March 21, 2025

A Pathology-Instructed Theranostic Platform with Mechanoadaptive and ROS-Powered Nanobreathing Functions for

Zheng Luo1,2,3, Cui Yang4, Liuzhou Mao2

  • 1Center of Burn & Plastic and Wound Healing Surgery, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 2, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of microwave extraction and chemical modification on physicochemical characteristic and bioactivity of Prunella vulgaris L. polysaccharide-dominated-conjugates.

International journal of biological macromolecules·2026
Same author

Two-step Xenogeneic Dermal Matrix-assisted Autologous Skin Grafting for Large Scalp Cutaneous Squamous Cell Carcinoma Ulcer.

Plastic and reconstructive surgery. Global open·2026
Same author

Mapping risk and opportunity: A space-based affiliation network analysis of physical and virtual spaces among high risk men.

Journal of acquired immune deficiency syndromes (1999)·2026
Same author

Comparative effectiveness of different inhaler technique education modalities on clinical outcomes in patients with asthma and chronic obstructive pulmonary disease: a protocol for a systematic review and network meta-analysis of randomised controlled trials.

BMJ open·2026
Same author

Preoperative Use of a Mobile Application Within the Multidisciplinary Team Approach - A Randomized Controlled Clinical Trial.

Obesity surgery·2026
Same author

Cyclosporine A protects against wasp venom-induced rhabdomyolysis in rats by inhibiting the CypD-mPTP pathway.

Toxicon : official journal of the International Society on Toxinology·2026

This study introduces a smart albumin hydrogel (BST) that dynamically responds to heart attack conditions, improving cardiac repair and survival. The biomaterial actively manages oxidative stress and promotes tissue regeneration for better heart function.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Regenerative Medicine

Background:

  • Current myocardial infarction (MI) biomaterials lack dynamic adaptation to the pathological microenvironment, leading to mechanical incompatibility and absent in situ feedback.
  • Existing treatments struggle to address evolving conditions like reactive oxygen species (ROS) bursts and hypoxia post-MI.

Purpose of the Study:

  • To develop an advanced albumin hydrogel platform (BST) with a closed-loop pathological response system for dynamic MI microenvironment adaptation.
  • To engineer a self-repairing scaffold with integrated imaging capabilities and targeted therapeutic delivery for enhanced cardiac repair.

Main Methods:

  • Development of a pH-responsive albumin hydrogel (BST) functionalized with MRI/CT probes and loaded with mitochondria-targeted CAT-SOD enzyme nanogels (CSDT).
Keywords:
Enzyme therapyMechanoadaptive protein hydrogelMitochondrial antioxidationMultimodal imagingMyocardial infarction

More Related Videos

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

Related Experiment Videos

Last Updated: Jul 3, 2026

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
08:29

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation

Published on: March 21, 2025

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

  • Characterization of BST's mechanical properties (viscosity, elasticity, cardiac-like mechanics) and its response to hypoxia-induced acidosis.
  • In vivo evaluation in an MI mouse model, assessing cardiac function, survival rates, angiogenesis, and immune modulation.

    • Main Results:

    • BST forms a mechanically compatible, self-repairing scaffold that stabilizes the infarct wall.
    • Hypoxia triggers CSDT release, leading to ROS scavenging and O2 generation, alleviating oxidative stress and promoting cardiomyocyte survival.
    • BST treatment significantly improved left ventricular ejection fraction (to ~70% of sham) and 28-day survival (by ~2.5-fold) in a mouse MI model.
    • Enhanced angiogenesis (~2.5-fold increase) and M2 macrophage polarization were observed, indicating a shift towards reparative processes.

    Conclusions:

    • The developed albumin hydrogel platform (BST) offers a novel, responsive biomaterial for myocardial infarction therapy.
    • BST's closed-loop system effectively reverses oxidative stress and hypoxia, promoting cardiac tissue regeneration and improving functional recovery.
    • Integrated imaging capabilities allow real-time tracking, enabling precision therapy and advancing the clinical translation of MI treatments.