Related Experiment Video

Updated: Oct 29, 2025

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.5K

Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection

Miguel Angel Martinez1, Sandra Franco2

  • 1IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain. mmartinez@irsicaixa.es.

Advances in Experimental Medicine and Biology
|July 14, 2021
PubMed

Insights

Chronic hepatitis C virus (HCV) infection affects millions globally. Direct-acting antiviral (DAA) therapies have revolutionized treatment, achieving nearly 100% cure rates and enabling global HCV eradication efforts.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • An estimated 71 million people worldwide lived with chronic hepatitis C virus (HCV) infection.
  • While some clear the infection spontaneously, most progress to chronic HCV, risking liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC).
  • Factors like age, alcohol, and HIV co-infection can accelerate disease progression.

Purpose of the Study:

  • To review the global burden of chronic hepatitis C virus (HCV) infection.
  • To highlight the impact of direct-acting antiviral (DAA) therapies on HCV cure rates and eradication potential.

Main Methods:

  • Review of epidemiological data on HCV prevalence.
  • Analysis of the clinical outcomes of chronic HCV infection.
  • Assessment of the efficacy of direct-acting antiviral (DAA) therapies.

Main Results:

  • Direct-acting antiviral (DAA) therapy, introduced in 2014, has achieved cure rates approaching 100% for chronic HCV.
  • DAAs represent a significant advancement in managing viral infections and offer a pathway to global HCV eradication.

Conclusions:

  • Direct-acting antiviral (DAA) therapy has transformed chronic hepatitis C (HCV) management.
  • The high efficacy of DAAs provides a realistic opportunity for the global eradication of HCV.

Keywords:
Direct-acting antiviral (DAA)HCVTherapy

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.4K
A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.4K

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
47.8K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
270