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Updated: Oct 28, 2025

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
Published on: June 23, 2022
Respiratory Pathogen Detection in Children: Saliva as a Diagnostic Specimen
Emma M de Koff1,2, Sjoerd M Euser3, Paul Badoux3
1From the Spaarne Academy, Spaarne Gasthuis, Hoofddorp and Haarlem, The Netherlands.
Abstract:
We compared pathogen detection between saliva, nasopharyngeal and oropharyngeal swabs in children with respiratory symptoms. The sensitivity in nasopharyngeal swabs was 93% (95% confidence interval [CI]: 78%-98%), in oropharyngeal swabs 79% (95% CI: 60%-90%), in saliva overall 76% (95% CI: 58%-88%) and in 18 saliva samples collected with drooling or sponges, 94% (95% CI: 74%-99%). Saliva could be a relevant specimen alternative.
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