Attention separates sensory and motor signals in the mouse visual cortex

Visually guided behaviors depend on the activity of cortical networks receiving visual inputs and transforming these signals to guide appropriate actions. However, non-retinal inputs, carrying motor signals as well as cognitive and attentional modulatory signals, also activate these cortical regions. How these networks integrate coincident signals ensuring reliable visual behaviors is poorly understood. In this study, we observe neural responses in the dorsal-parietal cortex of mice during a visual discrimination task driven by visual stimuli and movements. We find that visual and motor signals interact according to two mechanisms: divisive normalization and separation of responses. Interactions are contextually modulated by the animal's state of sustained attention, which amplifies visual and motor signals and increases their discriminability in a low-dimensional space of neural activations. These findings reveal computational principles operating in dorsal-parietal networks that enable separation of incoming signals for reliable visually guided behaviors during interactions with the environment.