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A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling

William W Du1, Jindong Xu1,2, Weining Yang1

  • 1Sunnybrook Research Institute, and Department of Laboratory Medicine and Pathobiology (W.W.D., J.X., W.Y., N.W., F.L., L.Z., X.L., A.T.H., K.Y.D., K.Z., J.M., J.L., C. Zhang, C. Zhou, K.M., B.B.Y.), University of Toronto, Canada.

Circulation Research
|July 15, 2021
PubMed

Keywords:
RNA, circularcollagenfibroblastsheart failurepeptides

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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