Celecoxib repurposing in cancer therapy: molecular mechanisms and nanomedicine-based delivery technologies

Area of Science:

• Oncology
• Pharmacology
• Nanotechnology

Background:

• Cancer is a major global health challenge.
• Advances in cancer biology enable targeted therapies.
• Drug repurposing offers cost-effective and safer alternatives to new drug development.

Purpose of the Study:

• To review the anticancer mechanisms of cyclooxygenase-2 (COX-2) inhibitors.
• To explore nanotechnological strategies for enhancing COX-2 inhibitor delivery.
• To focus on celecoxib's role in cancer chemoprevention and combination therapies.

Main Methods:

• Literature review of existing research on COX-2 inhibitors in cancer.
• Analysis of studies on nanodelivery systems for anticancer drugs.
• Examination of clinical and preclinical data for celecoxib in cancer treatment.

Main Results:

• COX-2 inhibitors demonstrate significant potential as anticancer agents.
• Nanotechnology-based delivery systems can improve the efficacy and targeting of COX-2 inhibitors.
• Celecoxib is a well-studied agent for chemoprevention and combination therapy.

Conclusions:

• Drug repurposing of COX-2 inhibitors is a viable strategy for cancer therapy.
• Nanotechnological approaches offer a promising avenue to optimize COX-2 inhibitor efficacy.
• Further research into celecoxib and other COX-2 inhibitors, enhanced by nanotechnology, is warranted.