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Updated: Oct 28, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Prenatal stress self-help mindfulness intervention via social media: a randomized controlled trial
Xuan Zhang1, Pingzhen Lin2, Jiwei Sun1
1School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong Province, China.
Background:
Prenatal stress is a pressing issue. However, there is a lack of robust evidence for psychosocial interventions to manage this problem.
Aims:
This study aimed to examine the effectiveness of a mindfulness-based intervention on reducing prenatal stress compared to participation in health education groups.
Methods:
A randomized controlled trial was conducted in a prenatal clinic of comprehensive tertiary care from April to October 2017. A total of 108 pregnant women were randomly assigned to an intervention or a control group. Participants completed self-report measures of depression, anxiety, perceived stress, fatigue, positive and negative affect, and mindfulness before, immediately after, and 15 weeks after the 4-week intervention period. Generalized estimating equations were used to analyze the intervention outcomes.
Results:
The results supported greater improvement in terms of perceived stress (Wald χ2=26.94, p<0.001), fatigue (Wald χ2=17.61, p<0.001), positive affect (Wald χ2=9.03, p = 0.011), negative affect (Wald χ2=11.37, p = 0.003), and mindfulness (Wald χ2=24.97, p<0.001) in the intervention group than in the control group.
Conclusions:
The self-help mindfulness intervention decreased prenatal stress and negative affect and improved positive affect and mindfulness.
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