Detection of Blood Glucose With Hemoglobin Content Using Compact Photonic Crystal Fiber

Area of Science:

• Photonics
• Biomedical Engineering
• Sensor Technology

Background:

• Accurate blood glucose monitoring is vital for diabetes management.
• Existing biosensors face limitations in sensitivity and detection range.
• Photonic Crystal Fibers offer unique light manipulation properties for sensing applications.

Purpose of the Study:

• To propose and analyze a novel Twin Elliptical Core Photonic Crystal Fiber (TEC-PCF) biosensor.
• To achieve enhanced sensitivity and a wide detection range for blood glucose levels.
• To investigate the influence of hemoglobin concentration on sensor performance.

Main Methods:

• Design of an asymmetric TEC-PCF with an elliptical core filled with a blood sample.
• Numerical simulation of sensing characteristics using the Finite Element Method (FEM).
• Analysis of coupling length and transmission power spectrum via effective index calculation.

Main Results:

• Enhanced blood glucose sensing achieved with a detection range of 0-100 g/L.
• Maximum wavelength sensitivity of 2.4 nm/(g/L) and 2.42 nm/(g/L) for X and Y polarization at 160 g/L hemoglobin.
• Limit of Detection (LOD) as low as 0.375 mg/L and 0.372 mg/L for X and Y polarization.

Conclusions:

• The proposed TEC-PCF sensor offers high sensitivity and a broad detection range for blood glucose.
• The miniaturized design is suitable for integration into microfluidic systems.
• This technology holds promise for next-generation point-of-care and lab-on-a-chip diagnostic devices.