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Respiratory function of rat brain mitochondria after hypobaric hypoxia and piracetam treatment
C Wustmann1, D Petzold, W Kunz
1Institute of Pharmacology and Toxicology, Medical Academy, Carl Gustav Carus, Dresden, GDR.
Biomedica Biochimica Acta
|January 1, 1987
Abstract:
After an acute hypobaric hypoxia the mitochondrial respiratory control index is reduced in consequence of a decreased active-state respiration. The finding is paralleled by decreased uncoupled respiration and a not significantly changed resting-state respiration. Long term hypoxic exposures show adaptive traits of this criterion of mitochondrial energy metabolism. The antihypoxic effect of piracetam may be reflected in a delayed normothermic in vitro aging of mitochondrial suspension.