Related Experiment Video
Updated: Oct 28, 2025

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
Published on: September 27, 2019
A Comparison of Label Switching Algorithms in the Context of Growth Mixture Models
Kristina R Cassiday1, Youngmi Cho2, Jeffrey R Harring1
1University of Maryland, College Park, MD, USA.
Abstract:
Simulation studies involving mixture models inevitably aggregate parameter estimates and other output across numerous replications. A primary issue that arises in these methodological investigations is label switching. The current study compares several label switching corrections that are commonly used when dealing with mixture models. A growth mixture model is used in this simulation study, and the design crosses three manipulated variables-number of latent classes, latent class probabilities, and class separation, yielding a total of 18 conditions. Within each of these conditions, the accuracy of a priori identifiability constraints, a priori training of the algorithm, and four post hoc algorithms developed by Tueller et al.; Cho; Stephens; and Rodriguez and Walker are tested to determine their classification accuracy. Findings reveal that, of all a priori methods, training of the algorithm leads to the most accurate classification under all conditions. In a case where an a priori algorithm is not selected, Rodriguez and Walker's algorithm is an excellent choice if interested specifically in aggregating class output without consideration as to whether the classes are accurately ordered. Using any of the post hoc algorithms tested yields improvement over baseline accuracy and is most effective under two-class models when class separation is high. This study found that if the class constraint algorithm was used a priori, it should be combined with a post hoc algorithm for accurate classification.
Related Concept Videos
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Mechanistic Models: Compartment Models in Individual and Population Analysis
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Comparing the Survival Analysis of Two or More Groups
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.

