Related Experiment Video
Updated: Oct 28, 2025
06:39
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
Published on: June 13, 2025
199
Heparin for Moderately Ill Patients with Covid-19
Medrxiv : the Preprint Server for Health Sciences
|July 16, 2021
Summary
Therapeutic heparin in COVID-19 patients did not significantly lower the composite outcome but reduced the odds of death. This suggests potential benefits for critically ill patients with elevated D-dimer levels.
Area of Science:
- Critical Care Medicine
- Pharmacology
- Infectious Diseases
Background:
- COVID-19 is associated with a thrombo-inflammatory process.
- Heparin exhibits anticoagulant, anti-inflammatory, and anti-viral properties.
- Early heparin initiation may mitigate severe COVID-19 outcomes.
Approach:
- Randomized trial comparing therapeutic heparin versus prophylactic heparin.
- Included moderately ill hospitalized COVID-19 patients with elevated D-dimer.
- Primary outcome: composite of death, mechanical ventilation, or ICU admission.
Key Points:
- Therapeutic heparin did not significantly reduce the composite outcome (16.2% vs. 21.9%).
- Therapeutic heparin significantly decreased 28-day mortality (1.8% vs. 7.6%).
- Major bleeding rates were similar between groups (0.9% vs. 1.7%).
Conclusions:
- In moderately ill COVID-19 patients with elevated D-dimer, therapeutic heparin did not meet the primary composite endpoint.
- Therapeutic heparin demonstrated a significant reduction in 28-day mortality.
- Further research may clarify heparin's role in managing COVID-19 complications.
Related Concept Videos
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.1K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.1K
01:29Venous Thrombosis III: Interprofessional Care
70
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
70
01:27Pulmonary Embolism III: Nursing Management
97
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
97
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
77
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
77
01:28Pneumonia IV: Management
528
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
528
01:30Venous Thrombosis IV: Nursing Management
62
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
62