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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

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Advances in anti-fungal therapies

Grant Waterer1

  • 1University of Western Australia, Royal Perth Hospital, Level 3 Executive Corridor, Wellington St, Perth, 6000, Australia. grant.waterer@uwa.edu.au.

Mycopathologia
|July 16, 2021
PubMed

Insights

New antifungal therapies are in development to combat rising drug resistance and improve treatment options. This review highlights promising agents in clinical trials, offering hope for more effective and less toxic treatments within 5-7 years.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • Current antifungal therapies are often suboptimal, leading to treatment failures.
  • Increasing antifungal resistance in pathogens necessitates the development of novel therapeutic agents.
  • There is a critical need for antifungal drugs with improved safety profiles and reduced toxicity.

Purpose of the Study:

  • To review antifungal therapies currently in Phase I human trials.
  • To provide clinicians with an overview of emerging antifungal agents.
  • To inform about the potential clinical availability of new antifungals in the next 5-7 years.

Main Methods:

  • Review of antifungal agents in at least Phase I human clinical trials.
  • Discussion of specific agents including modified azoles (VT-1161, VT-1598), rezafugin, ibrexafungerp, fosmanogepix, T-2307, olorofim, and ASP2397.
  • Analysis of available data on spectrum of activity, toxicity, and clinical development stage for each agent.

Main Results:

  • Several novel antifungal agents targeting different mechanisms are progressing through clinical development.
  • Agents include modified azoles, echinocandins, β-1,3-d-glucan synthase inhibitors, Gwt1 inhibitors, arylamidines, dihydroorotate inhibitors, and cyclic hexapeptides.
  • Data on spectrum, toxicity, and development stage are presented for each agent.

Conclusions:

  • Promising new antifungal agents are nearing clinical availability.
  • These novel therapies offer potential for improved efficacy and safety compared to existing treatments.
  • Clinicians can anticipate new options for managing fungal infections in the near future.
Keywords:
Anti-fungalDevelopmentPhase IIPhase III

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