Vogt-Koyanagi-Harada disease in Spain
Pedro Arriola-Villalobos1,2,3, Aina Moll-Udina4,5, Mario Carrasco-López-Brea6
1Servicio de Oftalmología, Hospital Clínico San Carlos, Departamento de Inmunología, Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain.
European Journal of Ophthalmology
|July 16, 2021
Summary
Vogt-Koyanagi-Harada (VKH) disease in Spain predominantly affects women and often presents as incomplete acute disease. Despite common complications like cataracts, visual outcomes for VKH patients are generally favorable.
Area of Science:
- Ophthalmology
- Immunology
- Epidemiology
Background:
- Vogt-Koyanagi-Harada (VKH) disease is a multisystem inflammatory disorder affecting pigmented tissues.
- Understanding its clinical and epidemiological profile is crucial for effective management.
Purpose of the Study:
- To delineate the clinical and epidemiological characteristics of Vogt-Koyanagi-Harada (VKH) disease in a Spanish cohort.
- To identify common presentations, treatments, and complications.
Main Methods:
- A retrospective multicenter analysis was conducted.
- Data from 112 VKH patients across 13 centers, followed for at least 6 months, were analyzed.
- Demographics, clinical features, treatments, and complications were collected.
Main Results:
- The study included 112 patients (224 eyes), with a mean age of 37.5 years; 83.9% were women.
- The disease was often incomplete (55.4%) and presented acutely (69.6%).
- Cataract (41.1%) and ocular hypertension (16.1%) were the most frequent complications, with corticosteroids being the primary treatment.
Conclusions:
- Vogt-Koyanagi-Harada (VKH) disease in Spain primarily impacts women and frequently manifests as incomplete acute disease.
- While cataracts and glaucoma are common complications, the visual prognosis for VKH patients is generally good.
- This study highlights the importance of early diagnosis and management to preserve visual acuity.
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