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Structure-function specialisation of the interfascicular matrix in the human achilles tendon
Dharmesh Patel1, Danae E Zamboulis2, Ewa M Spiesz3
1Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
Acta Biomaterialia
|July 16, 2021
Summary
The human Achilles tendon
Area of Science:
- Biomechanical engineering
- Musculoskeletal research
- Connective tissue biology
Background:
- Tendons are collagen-rich structures crucial for locomotion.
- Energy-storing tendons, like the Achilles, are prone to injury.
- The interfascicular matrix (IFM) role in human tendon energy storage is unknown.
Purpose of the Study:
- To investigate IFM specialization in human energy-storing (Achilles) versus positional (anterior tibial) tendons.
- To determine if IFM specialization changes with aging.
- To correlate IFM structure and function with tendon mechanics.
Main Methods:
- Comparative analysis of human Achilles and anterior tibial tendons.
- Mechanical testing (elasticity, fatigue resistance).
- Proteomics and immunolabelling to analyze IFM composition.
Main Results:
- Achilles tendon IFM shows specialized elasticity and fatigue resistance compared to the anterior tibial tendon.
- Aging significantly alters the Achilles IFM proteome.
- Age-related IFM changes correlate with decreased fatigue resistance.
Conclusions:
- The human Achilles tendon IFM is specialized for energy storage.
- Aging impacts Achilles IFM composition, potentially reducing its mechanical resilience.
- Understanding IFM specialization and aging effects is key for treating tendinopathy.
Keywords:
AgeingAnterior tibialis tendonFasciclesInterfascicular matrixMass spectrometryMechanical testingMore Related Videos
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