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Updated: Oct 28, 2025
09:29
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
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Post-COVID Neuromyelitis Optica Spectrum Disorder
Shumaila Rafique1, Areeba Wasim1, Tipu Sultan1
1Department of Pediatric Neurology, The Children Hospital, Lahore, Pakistan.
Summary
Severe acute respiratory syndrome (SARS) may trigger neuromyelitis optica spectrum disorder (NMOSD). This case study reports NMOSD in a pediatric patient following SARS-CoV-2 infection, suggesting a potential link between the virus and this autoimmune disorder.
Area of Science:
- Neurology
- Immunology
- Infectious Diseases
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has been linked to various immune-mediated disorders.
- Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune condition affecting the central nervous system, often triggered by infections.
Observation:
- This report details a pediatric case of NMOSD.
- The patient had a preceding infection with SARS-CoV-2.
Findings:
- The findings suggest a potential causal relationship between SARS-CoV-2 infection and the development of NMOSD in this pediatric patient.
- The study highlights the role of Aquaporin 4 (AQP-4) antibodies in NMOSD pathogenesis.
Implications:
- This case underscores the importance of considering SARS-CoV-2 as a potential trigger for NMOSD, even in pediatric populations.
- Further research is needed to elucidate the mechanisms linking viral infections to autoimmune demyelinating diseases like NMOSD.
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