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Acral persistent papular mucinosis.

Franco Rongioletti1, Caterina Ferreli1, Laura Atzori1

  • 1Dermatology Clinic, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Clinics in Dermatology
|July 17, 2021
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Summary
This summary is machine-generated.

Acral persistent papular mucinosis (APPM) is a rare skin condition presenting as persistent papules on the hands and forearms. This benign condition primarily affects women and requires no specific treatment.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Acral persistent papular mucinosis (APPM) is a localized variant of lichen myxedematosus.
  • APPM presents as chronic, skin-colored papules on the hands and forearms, predominantly in women.

Purpose of the Study:

  • To describe the clinical and histopathological characteristics of Acral persistent papular mucinosis.
  • To clarify the benign nature and prognosis of APPM.

Main Methods:

  • Clinical observation of patients with APPM.
  • Histopathological examination of skin biopsies, focusing on dermal mucin deposition.

Main Results:

  • APPM is characterized by papules on the extensor surfaces of hands and forearms.
  • Histopathology reveals focal dermal mucin accumulation in the upper dermis, sparing the grenz zone.
  • No systemic or laboratory abnormalities are associated with APPM.

Conclusions:

  • Acral persistent papular mucinosis is a benign dermatosis with a favorable prognosis.
  • Reassurance of patients regarding the condition's benign nature is recommended.
  • The etiology of APPM remains unknown.