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Structural and functional brain abnormalities in misophonia.

Nadine Eijsker1, Arjan Schröder1, Dirk J A Smit1

  • 1Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|July 17, 2021
PubMed
Summary
This summary is machine-generated.

Neuroimaging reveals structural and functional brain differences in misophonia (a sound sensitivity disorder). Patients show enlarged amygdala and altered connectivity, suggesting emotional and attention system dysfunction.

Keywords:
AmygdalaBiological psychiatryCerebellumGray matterMagnetic resonance imaging

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Misophonia is a disorder characterized by strong negative emotional reactions to specific sounds.
  • Limited evidence exists regarding the neurobiological underpinnings of misophonia.

Purpose of the Study:

  • To investigate structural and functional brain differences in individuals with misophonia compared to healthy controls.
  • To explore potential neurobiological correlates of heightened emotional reactivity and sensory processing in misophonia.

Main Methods:

  • Structural and resting-state functional magnetic resonance imaging (MRI) were used.
  • Voxel-based morphometry and seed-based functional connectivity analyses were performed on 24 misophonia patients and 25 controls.

Main Results:

  • Misophonia patients exhibited larger right amygdala volume compared to controls.
  • Altered functional connectivity was observed between the amygdala and cerebellum, and within the ventral attention network (lateral occipital cortices, fusiform gyri).

Conclusions:

  • Findings suggest structural and functional abnormalities in emotional and attentional brain systems in misophonia.
  • Enlarged amygdala may relate to emotional reactivity, while altered connectivity could underlie physical reactions and sensory processing differences.