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Nutrient Status in Patients with Frequent Episodic Tension-Type Headache: A Case-Control Study.

I Liampas¹, S Papathanasiou², N Tsikritsis³

¹Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Revue Neurologique

|July 19, 2021

Summary

Low vitamin D levels are linked to frequent episodic tension-type headaches (FE-TTH). This suggests a potential role for vitamin D in TTH development and warrants further investigation into supplementation strategies.

Keywords:

25(OH)D Folate Magnesium Vitamin B12 Vitamin D

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Area of Science:

Neurology
Nutritional Science
Epidemiology

Background:

Frequent episodic tension-type headache (FE-TTH) is a common neurological condition.
The role of specific micronutrients in the pathophysiology of FE-TTH requires further elucidation.

Purpose of the Study:

To investigate the association between FE-TTH and serum levels of 25-hydroxyvitamin-D (25(OH)D), folate, vitamin B12, and magnesium.
To explore secondary associations with demographic, lifestyle, and psychometric factors.

Main Methods:

A prospective case-control study comparing 30 adults with FE-TTH to 30 age- and sex-matched healthy controls.
Serum levels of 25(OH)D, folate, vitamin B12, and magnesium were measured.
Psychometric assessments for depression, anxiety, and sleep quality were conducted.

Main Results:

Lower serum 25(OH)D levels were significantly associated with FE-TTH (OR=0.72).
Serum magnesium was lower in the FE-TTH group only in univariate analysis.
Higher levels of anxiety and poor sleep quality were also associated with FE-TTH.

Conclusions:

Reduced serum 25(OH)D is a potential risk factor for FE-TTH.
Vitamin D may play a role in the pathophysiology of tension-type headaches.
Anxiety and poor sleep quality are also associated with FE-TTH.