Related Experiment Video

Updated: Oct 28, 2025

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
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Ibrutinib-Associated Cardiovascular Events in a Patient Wearing an Implanted Loop Recorder

Daniel Rivera1, Koichi Takahashi1, Jean-Bernard Durand2

  • 1Department of Leukemia, The University of Texas MD Anderson Cancer Center.

Mediterranean Journal of Hematology and Infectious Diseases
|July 19, 2021
PubMed

Insights

Ibrutinib effectively treats chronic lymphocytic leukemia (CLL) but can cause cardiac arrhythmias like atrial fibrillation. Implanted loop recorders aid in managing these cardiovascular events in CLL patients on ibrutinib.

Area of Science:

  • Cardiology
  • Hematology
  • Oncology

Background:

  • Ibrutinib is a targeted therapy for chronic lymphocytic leukemia (CLL).
  • Cardiovascular events, including arrhythmias like atrial fibrillation (Afib), are known side effects of ibrutinib.
  • Cardiac arrhythmias pose significant risks for morbidity and mortality.

Observation:

  • This case report details the experience with a patient diagnosed with CLL who was treated with ibrutinib.
  • The patient experienced cardiovascular events necessitating management.

Findings:

  • Implanted loop recorders (ILRs) are increasingly used in clinical practice.
  • ILRs can be valuable tools for diagnosing and guiding the management of cardiac arrhythmias.
  • This case illustrates the utility of ILRs in a patient with CLL on ibrutinib experiencing arrhythmias.

Implications:

  • Early detection and management of ibrutinib-associated cardiac arrhythmias are crucial.
  • Implanted loop recorders may play a key role in optimizing patient care and outcomes.
  • Further research into managing cardiovascular toxicities of targeted cancer therapies is warranted.

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