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Updated: Oct 28, 2025
Determining the Toxicity of UV Radiation and Chemicals on Primary and Immortalized Human Corneal Epithelial Cells
Published on: July 22, 2021
Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
Ermi Girsang1, Chrismis N Ginting1, I Nyoman Ehrich Lister1
1Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia.
Background:
Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress.
Objective:
This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells.
Methods:
Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level.
Results:
Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression.
Conclusion:
CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.
