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Chloride intracellular channels as novel biomarkers for digestive system tumors (Review)

Hui Wang1, Jiaxing An1, Suyu He2

  • 1Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.

Molecular Medicine Reports
|July 19, 2021
PubMed

Insights

Chloride intracellular channels (CLICs) show altered expression and function in digestive system tumors, suggesting their potential as novel biomarkers for early cancer detection and targeted therapy. This review explores CLICs

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Digestive system malignant tumors present diagnostic challenges, with difficulties in early detection and monitoring postoperative recurrence.
  • Traditional treatments like surgery, radiotherapy, and chemotherapy have limitations, necessitating novel diagnostic and therapeutic strategies.
  • Chloride channels play a significant role in cancer development, proliferation, apoptosis, and cell cycle regulation.

Purpose of the Study:

  • To review the role of Chloride Intracellular Channels (CLICs) as potential biomarkers in digestive system tumors.
  • To explore the diagnostic and therapeutic potential of CLICs in oncology.
  • To highlight the altered expression and function of CLICs during cancer progression.

Main Methods:

  • Literature review focusing on studies investigating CLICs in various cancers.
  • Analysis of research on the expression patterns and functional alterations of CLICs in digestive system tumors.
  • Examination of the cell cycle-dependent localization and activity of CLICs.

Main Results:

  • Chloride intracellular channels (CLICs) are differentially expressed (upregulated or downregulated) in digestive system cancers.
  • Altered localization and function of the cytosolic form of CLICs are observed during cell cycle progression.
  • These changes indicate CLICs' potential as key targets for cancer therapy and diagnosis.

Conclusions:

  • CLICs represent promising biomarkers for the early diagnosis of digestive system tumors.
  • The specific roles and alterations of CLICs in digestive system cancers warrant further investigation for therapeutic targeting.
  • Targeting CLICs could offer novel avenues for managing digestive system malignancies.
Keywords:
anionchloridechloride intracellular channelsdigestive system tumorsion channel

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