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Iron Single Atom Catalyzed Quinoline Synthesis.

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  • 1Department of Chemistry, 3 Science Drive 3, Singapore, 117543, Singapore.

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New carbon plates immobilize single-atom catalysts (SACs) for efficient liquid-phase chemical synthesis. This approach enhances catalyst stability and activity, enabling the production of valuable quinoline compounds with high selectivity.

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hierarchically porous structureorganic catalysisoxidative cyclizationsingle-atom catalyststhree-component reaction

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Area of Science:

  • Catalysis
  • Materials Science
  • Organic Chemistry

Background:

  • Single-atom catalysis (SAC) offers high selectivity for chemical production.
  • Liquid-phase SAC applications are limited by poor reactant activation and catalyst instability.
  • Immobilization strategies are needed to improve SAC performance in solution.

Purpose of the Study:

  • To develop mechanically strong, hierarchically porous carbon plates for SAC immobilization.
  • To enhance the activity and stability of SACs in liquid-phase reactions.
  • To demonstrate the utility of immobilized SACs for synthesizing high-value chemicals.

Main Methods:

  • Fabrication of hierarchically porous carbon plates.
  • Immobilization of single-atom catalysts onto carbon supports.
  • Application of immobilized SACs in three-component oxidative cyclization reactions.
  • Synthesis of substituted quinolines and deuteration of quinolines.

Main Results:

  • The developed carbon plates successfully immobilized SACs, enhancing catalytic activity and stability.
  • High selectivity (≈68%) was achieved for the synthesis of substituted quinolines.
  • A wide range of quinolines (23 examples) were synthesized efficiently and atom-economically.
  • A Cavosonstat derivative was synthesized in one step, and challenging deuteration was achieved.

Conclusions:

  • Mechanically strong, hierarchically porous carbon plates are effective supports for immobilizing SACs.
  • Immobilized SACs demonstrate excellent performance in liquid-phase synthesis of quinolines.
  • This strategy offers a promising, scalable, and reusable approach for industrial catalysis.