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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
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The Link Between Conventional and Novel Anti-Cancer Therapeutics with Thrombotic Microangiopathy

Carmen E Cervantes1, Sam Kant1, Mohamed G Atta1

  • 1Department of Medicine, Division of Nephrology, Johns Hopkins University, Baltimore, Maryland MD 21218, United States.

Drug Metabolism Letters
|July 19, 2021
PubMed
Abstract

Insights

Cancer therapies can harm kidneys, a growing concern in onco-nephrology. Understanding drug-induced kidney damage is crucial for safe and effective cancer treatment, especially with unreliable kidney function tests in patients.

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Kidney disease is increasingly linked to cancer and its treatments.
  • Drug-induced nephrotoxicity is a significant concern due to the inherent risks of chemotherapeutic agents.
  • Standard kidney function tests may be inaccurate in cancer patients, potentially leading to overestimated glomerular filtration rates.

Purpose of the Study:

  • To review drug-induced thrombotic microangiopathy in cancer patients.
  • To explore the immune/idiosyncratic and non-immune/dose-dependent mechanisms of this condition.

Main Methods:

  • Literature review focusing on drug-induced thrombotic microangiopathy.
  • Analysis of pathophysiologic mechanisms of thrombotic microangiopathy.

Main Results:

  • Drug-induced thrombotic microangiopathy presents with distinct immune and non-immune mechanisms.
  • Overestimation of kidney function can exacerbate nephrotoxicity and limit treatment options.

Conclusions:

  • A deeper understanding of conventional and novel chemotherapeutic agents is essential.
  • Continued research in onco-nephrology is vital as cancer therapies evolve.
Keywords:
Acute kidney injurychemotherapydrug-inducedimmunotherapy.nephrotoxicthrombotic microangiopathy

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