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Topical Oral and Intranasal Antiviral Agents for Coronavirus Disease 2019 (COVID-19)

Victor B Hsue1, Kyohei Itamura1, Arthur W Wu1

  • 1Department of Otolaryngology-Head and Neck Surgery, Cedars Sinai, Los Angeles, CA, USA.

Advances in Experimental Medicine and Biology
|July 19, 2021
PubMed

Insights

Agents targeting the oral and nasal cavities show promise for treating and preventing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Further clinical and safety trials are needed to confirm efficacy for coronavirus disease 2019 (COVID-19).

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral loads are highest in the oral and nasal cavities.
  • Targeting these areas offers potential for therapeutic and prophylactic benefits against coronavirus disease 2019 (COVID-19).

Purpose of the Study:

  • To review and evaluate agents with potential efficacy against SARS-CoV-2 in the oral and nasal cavities.
  • To assess their current applications, adverse reactions, and stage of research for COVID-19 management.

Main Methods:

  • A comprehensive literature review was conducted.
  • Agents were evaluated based on in-vitro efficacy, clinical trial status, and safety data.

Main Results:

  • Multiple agents demonstrated in-vitro efficacy against SARS-CoV-2.
  • Significant potential exists for agents acting on oral and nasal cavities.

Conclusions:

  • Promising agents require further clinical trials and in-vivo studies.
  • Extensive safety trials are necessary before widespread implementation for COVID-19 treatment and prevention.
Keywords:
Antiviral agentsCOVID-19CoronavirusNasalNasopharynxOralPublic healthSevere acute respiratory syndrome coronavirus 2Topical

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