Related Experiment Video

Updated: Oct 27, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

911

The MMP-1 Gene rs1799750 Polymorphism Is Associated with Breast Cancer Risk

Jun Sui1, Jing Huang1, YongChen Zhang1

  • 1Department of Laboratory Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.

Genetic Testing and Molecular Biomarkers
|July 19, 2021
PubMed

Insights

The matrix metalloproteinase-1 (MMP-1) gene rs1799750 polymorphism may reduce breast cancer risk, particularly in Asian populations. Further research is needed to confirm this association with breast cancer susceptibility.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Inconsistent findings exist regarding the association between the matrix metalloproteinase-1 (MMP-1) gene rs1799750 polymorphism and breast cancer (BC) risk.
  • A precise estimation of the association between this genetic locus and BC susceptibility is needed.

Purpose of the Study:

  • To conduct a meta-analysis to determine the association between the MMP-1 gene rs1799750 polymorphism and breast cancer susceptibility.

Main Methods:

  • Systematic literature search of PubMed, Google, CNKI, and EMBASE databases.
  • Inclusion of eight eligible studies with 3439 cases and 3517 controls, data collected up to October 1, 2020.
  • Meta-analysis performed under the heterozygous model.

Main Results:

  • The MMP-1 rs1799750 polymorphism was associated with a reduced BC risk in the overall population.
  • Stratification analysis revealed a stronger association in Asian populations.
  • The MMP-1 rs1799750 polymorphism acts as a decreased risk factor for BC.

Conclusions:

  • Evidence suggests an association between the MMP-1 rs1799750 polymorphism and reduced BC susceptibility.
  • The MMP-1 rs1799750 polymorphism may serve as a protective factor against breast cancer.
  • Further studies with diverse ethnic populations are recommended to validate these findings.
Keywords:
MMP-1breast cancermeta-analysispolymorphism

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.4K
gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.4K

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.8K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.0K
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.5K
Mismatch Repair01:36

Mismatch Repair

Overview
41.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K