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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
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Weather conditions associated with subarachnoid hemorrhage: a multicenter case-crossover study
Michael Kockler1, Peter Schlattmann2, Mario Walther3
1Hans-Berger Department of Neurology, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
BMC Neurology
|July 20, 2021
Summary
High atmospheric pressure may slightly increase subarachnoid hemorrhage (SAH) risk, but weather changes and temperature do not appear to be significant risk factors. Further research is needed to confirm these findings, especially with climate change.
Area of Science:
- Neurology
- Environmental Medicine
- Epidemiology
Background:
- Spontaneous subarachnoid hemorrhage (SAH) often occurs without identifiable risk factors.
- Climate variability prompts investigation into environmental factors, such as weather, as potential short-term SAH triggers.
Purpose of the Study:
- To investigate the association between weather conditions, including rapid weather changes, and the short-term risk of spontaneous subarachnoid hemorrhage (SAH).
Main Methods:
- A hospital-based case-crossover study involving 791 patients with non-traumatic SAH in Germany.
- Analysis of atmospheric pressure, relative air humidity, ambient temperature, and their 24-hour changes in relation to SAH onset.
Main Results:
- No significant association was found between SAH risk and 24-hour weather changes, mean daily temperature, or mean relative air humidity.
- A statistically weak increase in SAH risk (15%) was observed with a 3-day lag for every 11.5 hPa rise in mean daily atmospheric pressure.
Conclusions:
- Weather changes, temperature, and humidity do not appear to be relevant risk factors for SAH.
- The clinical significance of the observed weak association between high atmospheric pressure and SAH risk remains unclear.
- Further studies in diverse geographical regions are recommended to validate these findings, particularly in the context of increasing high-pressure systems due to global warming.

