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Sirtuin 6: linking longevity with genome and epigenome stability
Anatoly Korotkov1, Andrei Seluanov1, Vera Gorbunova1
1Departments of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.
Trends in Cell Biology
|July 20, 2021
Summary
Sirtuin 6 (SIRT6) is crucial for genome stability and longevity. Enhancing SIRT6 levels may reverse aging by maintaining epigenetic silencing of repetitive elements.
Area of Science:
- Molecular Biology
- Genetics
- Aging Research
Background:
- Sirtuin 6 (SIRT6) deficiency is linked to progeroid phenotypes, highlighting its importance in aging.
- SIRT6 regulates DNA repair and heterochromatin, acting as a central hub for genome and epigenome stability.
Purpose of the Study:
- To review the role of SIRT6 in maintaining genome and epigenome stability.
- To explore the connection between SIRT6 and longevity.
- To propose a model for SIRT6 in aging and rejuvenation.
Main Methods:
- Literature review focusing on SIRT6 function in aging.
- Analysis of SIRT6's roles in DNA repair and epigenetic regulation.
- Synthesis of evidence linking SIRT6 to genome stability and longevity.
Main Results:
- Genomic instability, epigenetic alterations, and derepression of repetitive elements drive organismal aging.
- Enhanced SIRT6 expression or activity presents a potential rejuvenation strategy.
- SIRT6 is integral to maintaining the epigenetic silencing of repetitive genetic elements.
Conclusions:
- SIRT6 plays a vital role in genome and epigenome maintenance, impacting longevity.
- A model is proposed where SIRT6 and lamins control aging by silencing repetitive elements.
- Targeting SIRT6 offers a promising avenue for developing anti-aging interventions.
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