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"Negative growth" in anorexia nervosa assessed by knemometry
M Hermanussen1, K Geiger-Benoit, W G Sippell
1Universitätskinderklinik, Kiel, Federal Republic of Germany.
European Journal of Pediatrics
|November 1, 1987
Summary
This study demonstrates long-term lower leg shrinkage in two children with anorexia nervosa, measured using knemometry. The findings suggest potential growth plate atrophy as a cause for this unprecedented shrinkage in pediatric patients.
Area of Science:
- Pediatric Endocrinology
- Growth and Development
- Anorexia Nervosa Research
Background:
- A novel non-invasive technique, knemometry, accurately measures lower leg length.
- Anorexia nervosa can significantly impact a child's overall health and development.
- Understanding growth patterns in pediatric patients with eating disorders is crucial.
Observation:
- Two female patients with anorexia nervosa (aged 14:4 and 13:7) were monitored using knemometry.
- Patient 1 exhibited significant lower leg shrinkage (-0.040 mm/day) during hospitalization.
- Patient 2 showed significant lower leg shrinkage (-0.009 mm/day) post-discharge.
Findings:
- This study provides the first documented evidence of long-term lower leg shrinkage in children.
- The observed shrinkage is distinct from measurement error or soft tissue changes.
- Shrinkage persisted even with weight gain, indicating a deeper physiological process.
Implications:
- The findings suggest potential progressive atrophic changes in the epiphyseal plates of affected children.
- Further research is needed to elucidate the exact mechanisms behind this phenomenon.
- Knemometry may serve as a valuable tool for monitoring growth disturbances in pediatric eating disorders.