Related Experiment Video

Updated: Oct 27, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

542

[Endothelial dysfunction in COVID- 19 and cognitive impairment]

M Yu Martynov1,2, A N Bogolepova1,2, A N Yasamanova1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 20, 2021
PubMed

Insights

COVID-19 causes endothelial dysfunction, impacting organ perfusion and leading to blood clots. Actovegin may improve endothelial function and cognitive impairment in these patients.

Area of Science:

  • Cardiovascular Biology
  • Neuroscience
  • Infectious Diseases

Background:

  • Endothelial dysfunction is a key factor in COVID-19 multi-organ failure.
  • It disrupts organ perfusion and promotes thrombotic events.
  • Cognitive impairment is a frequent COVID-19 complication, irrespective of disease severity.

Purpose of the Study:

  • To investigate the role of endothelial dysfunction in COVID-19.
  • To explore therapeutic strategies for COVID-19-associated endothelial dysfunction and cognitive impairment.

Main Methods:

  • Review of mechanisms underlying endothelial dysfunction in COVID-19.
  • Analysis of neuroprotective treatments for COVID-19 complications.

Main Results:

  • Endothelial dysfunction contributes to organ failure and thrombosis in COVID-19.
  • Actovegin demonstrates efficacy in enhancing endothelial function, microcirculation, and cognition.

Conclusions:

  • Targeting endothelial dysfunction is crucial for managing COVID-19.
  • Actovegin shows promise as a neuroprotective agent for cognitive deficits in COVID-19 patients.

Keywords:
COVID-19SARS-CoV-2actovegincognitive impairmentendothelial dysfunctionmolecular mimicry

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