Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

877
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
877
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

412
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
412
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

96
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
96
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

115
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
115
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

132
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
132
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.4K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Postischemic reperfusion and "reperfusion paradox" in ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same author

[Cognitive health of Moscow residents 55 years and older: Epidemiological data].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same author

[Myoclonus in Alzheimer's disease].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same author

[Therapy prospects for post-stroke aphasia].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same author

[Fortelyzin in the treatment of acute ischemic stroke in patients ≥80 years old: data from the observational study FORPI registry].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same author

[Results of the program to preserve cognitive skills and psycho-emotional health in Moscow Longevity Centers].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026

Related Experiment Video

Updated: Oct 27, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

542

[Endothelial dysfunction in COVID- 19 and cognitive impairment].

M Yu Martynov1,2, A N Bogolepova1,2, A N Yasamanova1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 20, 2021
PubMed
Summary

COVID-19 causes endothelial dysfunction, impacting organ perfusion and leading to blood clots. Actovegin may improve endothelial function and cognitive impairment in these patients.

Keywords:
COVID-19SARS-CoV-2actovegincognitive impairmentendothelial dysfunctionmolecular mimicry

More Related Videos

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

7.9K
Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
06:40

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

Published on: March 11, 2022

3.9K

Related Experiment Videos

Last Updated: Oct 27, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

542
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

7.9K
Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
06:40

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

Published on: March 11, 2022

3.9K

Area of Science:

  • Cardiovascular Biology
  • Neuroscience
  • Infectious Diseases

Background:

  • Endothelial dysfunction is a key factor in COVID-19 multi-organ failure.
  • It disrupts organ perfusion and promotes thrombotic events.
  • Cognitive impairment is a frequent COVID-19 complication, irrespective of disease severity.

Purpose of the Study:

  • To investigate the role of endothelial dysfunction in COVID-19.
  • To explore therapeutic strategies for COVID-19-associated endothelial dysfunction and cognitive impairment.

Main Methods:

  • Review of mechanisms underlying endothelial dysfunction in COVID-19.
  • Analysis of neuroprotective treatments for COVID-19 complications.

Main Results:

  • Endothelial dysfunction contributes to organ failure and thrombosis in COVID-19.
  • Actovegin demonstrates efficacy in enhancing endothelial function, microcirculation, and cognition.

Conclusions:

  • Targeting endothelial dysfunction is crucial for managing COVID-19.
  • Actovegin shows promise as a neuroprotective agent for cognitive deficits in COVID-19 patients.