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Updated: Oct 27, 2025

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Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection

Kevin Y Wang1, Pratik Shah2, Dennis T Roarke3

  • 1Department of Internal Medicine, NSLIJ Health System, New Hyde Park, New York, USA Kevwangyu@gmail.com.

BMJ Case Reports
|July 21, 2021
PubMed

A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports.

Keywords:
COVID-19Haematology (drugs and medicines)

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