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Immune-based therapies in cardiovascular and metabolic diseases: past, present and future

Andrew J Murphy1, Mark A Febbraio2

  • 1Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia. andrew.murphy@baker.edu.au.

Nature Reviews. Immunology
|July 21, 2021
PubMed

Insights

Cardiometabolic disorders, once linked solely to lipid metabolism, are now understood to involve immune system roles. Immunotherapies show promise for treating these conditions, shifting focus from traditional lipid-lowering drugs.

Area of Science:

  • Immunology
  • Metabolic disease
  • Cardiovascular research

Background:

  • Cardiometabolic disorders were historically attributed to lipid metabolism dysregulation.
  • Statins, lipid-lowering drugs, have been the primary treatment for cardiovascular disease.
  • Recent discoveries highlight the significant role of the innate and adaptive immune systems in these disorders.

Purpose of the Study:

  • To review the historical perspective of cardiometabolic disorders.
  • To discuss the evolving understanding of immune system involvement.
  • To explore the potential of immunotherapies in treating cardiometabolic diseases.

Main Methods:

  • Literature review of historical and recent research.
  • Analysis of preclinical studies on immune-targeted therapies.
  • Discussion of clinical trial limitations and future directions.

Main Results:

  • Cardiometabolic disorders involve complex immune system pathways.
  • Immune-based interventions are emerging as a significant therapeutic strategy.
  • Preclinical data strongly supports the efficacy of immune-targeted treatments.

Conclusions:

  • The understanding of cardiometabolic disorders has expanded beyond lipid metabolism to include immune system dysregulation.
  • Immunotherapies represent a promising frontier for managing and treating cardiometabolic diseases.
  • Further clinical trials are warranted to validate the therapeutic potential of immune-targeted strategies.

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