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Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer

Danial Mehranfard1, Gabriela Perez2, Andres Rodriguez3

  • 1College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.

Journal of the Renin-Angiotensin-Aldosterone System : JRAAS
|July 21, 2021
PubMed
Abstract

Insights

This study reveals altered gene expression in colorectal cancer (CRC). Key genes in the renin-angiotensin system (RAS) are dysregulated, suggesting potential therapeutic targets for CRC treatment.

Area of Science:

  • Genomics
  • Molecular Biology
  • Cancer Research

Background:

  • The renin-angiotensin system (RAS) plays a role in various physiological processes.
  • Dysregulation of the RAS has been implicated in cancer development and progression.

Purpose of the Study:

  • To investigate the expression patterns of specific RAS-related genes in colorectal cancer (CRC).
  • To identify potential molecular mechanisms linking RAS to CRC oncogenicity.

Main Methods:

  • Quantitative gene expression analysis using chip arrays.
  • Statistical comparison of gene expression in normal versus cancerous tissues from the Gene Expression Omnibus (GEO) database.

Main Results:

  • Upregulation of angiotensinogen (AGT), aminopeptidase A (ENPEP), neprilysin (MME), and prolyl endopeptidase (PREP) in CRC specimens.
  • Downregulation of renin (REN), thimet oligopeptidase (THOP), neurolysin (NLN), prolyl carboxypeptidase (PRCP), aminopeptidase N (ANPEP), and Mas receptor (MAS1) in CRC specimens.

Conclusions:

  • Altered expression of RAS components suggests a potential role in CRC development.
  • Increased angiotensinogen and reduced metabolism may lead to angiotensinogen accumulation in CRC.
  • Downregulation of the ACE2/ANG 1-7/Mas axis may promote oncogenicity.
  • RAS components represent potential therapeutic targets for CRC treatment.

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