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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Related Experiment Video

Updated: Oct 27, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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CCL25 Signaling in the Tumor Microenvironment.

Hina Mir1,2, Shailesh Singh3,4,5

  • 1Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.

Advances in Experimental Medicine and Biology
|July 21, 2021
PubMed
Summary

Cancer cells manipulate the tumor microenvironment (TME) by overriding checkpoints. The CCR9-CCL25 chemokine axis is crucial for cancer growth, immune suppression, and metastasis.

Keywords:
AngiogenesisCCL25CCR9ChemoresistanceDendritic cellsExtracellular matrixMMPMacrophagesMetastasisT cellsTGF-βTumor microenvironmentVEGF

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Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Cancer cells evade immune surveillance by overriding checkpoint mechanisms.
  • Tumor progression involves neoplastic cells altering their microenvironment and signaling pathways.
  • The tumor microenvironment (TME) plays a critical role in cancer development and metastasis.

Purpose of the Study:

  • To comprehend non-cancer cells that facilitate tumor growth.
  • To elaborate on the role of the CCR9-CCL25 chemokine axis in shaping the TME.
  • To review current research on targeting the CCR9-CCL25 axis for cancer therapy.

Main Methods:

  • Literature review and synthesis of existing research on the CCR9-CCL25 axis in cancer.
  • Analysis of the mechanisms by which this axis influences immune cells and the extracellular matrix.
  • Examination of the association between CCR9 and CCL25 levels and tumor progression.

Main Results:

  • Increased CCR9 and CCL25 levels are significantly associated with various tumors, highlighting the axis's importance in cancer progression.
  • The CCR9-CCL25 axis attracts and determines the fate of immune cells, promoting an immunosuppressive TME.
  • This signaling pathway supports cancer cell survival, proliferation, and metastasis by modulating the extracellular matrix and creating metastatic niches.

Conclusions:

  • The CCR9-CCL25 chemokine axis is a key player in tumor progression, immune evasion, and metastasis.
  • Targeting this axis presents a promising strategy for cancer therapy.
  • Further research is needed to overcome challenges in utilizing the CCR9-CCL25 axis as a cancer-specific therapeutic target.