Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

91
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
91
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

74
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
74
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.3K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.3K
Stem Cell Culture01:17

Stem Cell Culture

5.7K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.7K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

102
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
102

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association Between Complications and Death Within 30 Days After Orthopedic Surgery: Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy.

JMIR perioperative medicine·2026
Same author

Association between complications and mortality after cardiac surgery: Results from the Vascular Events in Surgery Patients Cohort Evaluation cardiac surgery prospective cohort study.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Evaluation of cardiac histology and cell death markers during the progression of diabetes in a streptozotocin-induced diabetes rat model.

Animal models and experimental medicine·2026
Same author

Integrating Planetary Health in Health Guidelines (GRADE Guidance 46).

Annals of internal medicine·2026
Same author

Congestion, Obesity, and Survival in Chronic Heart Failure.

Journal of cardiac failure·2026
Same author

ASSOCIATION BETWEEN COMPLICATIONS AND DEATH WITHIN 30 DAYS AFTER ORTHOPEDIC SURGERY: A VASCULAR EVENTS IN NONCARDIAC SURGERY PATIENTS COHORT EVALUATION (VISION) SUBSTUDY.

JMIR perioperative medicine·2026
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: Oct 27, 2025

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
10:16

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

8.0K

Stem cell therapy for dilated cardiomyopathy.

Rienzi Diaz-Navarro1, Gerard Urrútia2, John Gf Cleland3

  • 1Department of Internal Medicine, School of Medicine, Universidad de Valparaiso, Vina del Mar, Chile.

The Cochrane Database of Systematic Reviews
|July 21, 2021
PubMed
Summary
This summary is machine-generated.

The effectiveness of stem cell therapy (SCT) for dilated cardiomyopathy (DCM) remains uncertain. While some studies suggest potential benefits in cardiac function, evidence for improved mortality or quality of life is low-certainty, warranting further research.

More Related Videos

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
06:37

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

8.5K
Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity
08:00

Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity

Published on: July 10, 2019

6.3K

Related Experiment Videos

Last Updated: Oct 27, 2025

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
10:16

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

8.0K
Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
06:37

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

8.5K
Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity
08:00

Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity

Published on: July 10, 2019

6.3K

Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Dilated cardiomyopathy (DCM) is a condition where the heart's main pumping chamber weakens and enlarges.
  • Stem cell therapy (SCT) has been investigated as a potential treatment for DCM, but its efficacy is debated.

Purpose of the Study:

  • To evaluate the effectiveness and safety of stem cell therapy (SCT) in adult patients diagnosed with non-ischaemic dilated cardiomyopathy (DCM).
  • To synthesize evidence from randomized controlled trials (RCTs) comparing SCT with control interventions.

Main Methods:

  • A systematic literature search was conducted across major databases (CENTRAL, MEDLINE, Embase) and clinical trial registers.
  • Included studies were RCTs comparing stem/progenitor cells versus no cells in non-ischaemic DCM patients.
  • Meta-analyses were performed to quantitatively evaluate data, with evidence certainty assessed using the GRADE approach.

Main Results:

  • Thirteen RCTs involving 762 participants were analyzed, with significant limitations in study quality and risk of bias.
  • Evidence regarding SCT's impact on all-cause mortality, procedural complications, health-related quality of life (HRQoL), and functional capacity was of very low to low certainty.
  • Some physiological measures of cardiac function showed potential benefits, but translation to clinical outcomes remains unclear.

Conclusions:

  • Current evidence is insufficient to confirm the benefits of SCT for reducing mortality or improving HRQoL and exercise capacity in DCM patients.
  • While SCT may offer some functional class improvements, uncertainties regarding safety and optimal application persist.
  • The use of SCT for DCM should be limited to clinical research settings, pending results from ongoing studies.