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Dissolution profiles of fenbendazole from binary solid dispersions: a mathematical approach.
María Elisa Melian1,2, Cintia Alejandra Briones Nieva3, Laura Domínguez1
1Área de Farmacología, CIENFAR, Facultad de Química, Universidad de la República, Montevideo, 11800, Uruguay.
Therapeutic Delivery
|July 21, 2021
Summary
Solid dispersions (SDs) significantly enhance fenbendazole dissolution, showing a 500-fold increase in release rate compared to physical mixtures. Formulation type, not polymer characteristics, is key for predictable drug performance.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Developing drug formulations with predictable in vivo performance is crucial.
- Solid dispersions (SDs) offer potential for improving drug dissolution and bioavailability.
Purpose of the Study:
- To understand the drug dissolution process of fenbendazole from solid dispersions (SDs).
- To develop formulations with predictable in vivo performance.
Main Methods:
- Dissolution data of fenbendazole from SDs and physical mixtures were analyzed.
- The Lumped mathematical model was employed to estimate relevant pharmaceutical parameters.
Main Results:
- SDs exhibited a unique dissolution profile with an error of ±4.1%.
- The initial release rate from SDs was 500 times higher than the pure drug.
- Drug/polymer ratio and polymer type did not affect the dissolution profile.
Conclusions:
- The Lumped model elucidated that formulation type (SD vs. physical mixture) is the primary determinant of fenbendazole release.
- Polymer type and quantity were found to be non-influential factors on drug release kinetics.
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