Related Experiment Video

Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

832

Retraction

    Journal of Cellular Biochemistry
    |July 21, 2021
    PubMed

    Insights

    This study on breast cancer cells has been retracted due to invalid experimental data. The inhibition of the Notch signaling pathway's effect on radiosensitivity is therefore unsubstantiated.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cell Biology

    Context:

    • The study investigated the role of the Notch signaling pathway in breast cancer radiosensitivity.
    • Allegations of data manipulation prompted an investigation into the published findings.

    Purpose:

    • To assess the impact of inhibiting the Notch signaling pathway on the radiosensitivity of breast cancer cells.
    • To determine if Notch pathway inhibition could enhance the effectiveness of radiation therapy in breast cancer.

    Summary:

    • The article "Inhibition of Notch signaling pathway enhanced the radiosensitivity of breast cancer cells" has been retracted.
    • The retraction was based on the discovery that experimental data images were used in other scientific contexts.
    • The journal editors deemed the article's conclusions invalid due to these data integrity issues.

    Impact:

    • The retraction invalidates any conclusions drawn from the study regarding Notch signaling and breast cancer radiosensitivity.
    • This case highlights the importance of rigorous data verification in scientific publishing.
    • Researchers should be aware that the findings presented in this article are no longer considered valid.

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