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Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
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Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

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Retraction

    Journal of Cellular Biochemistry
    |July 21, 2021
    PubMed

    Insights

    This study on hepatocellular carcinoma has been retracted due to significant flaws. The original findings regarding LINC01551 and microRNA-122-5p are considered invalid by the editors.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biochemistry

    Context:

    • Investigated the role of long noncoding RNA LINC01551 in hepatocellular carcinoma (HCC).
    • Explored the interaction between LINC01551, microRNA-122-5p, and ADAM10 in cancer progression.

    Purpose:

    • To elucidate the mechanism by which LINC01551 promotes HCC cell proliferation, migration, and invasion.
    • To determine if LINC01551 acts as a competing endogenous RNA (ceRNA) for microRNA-122-5p.

    Summary:

    • The article originally proposed that LINC01551 enhances HCC progression by sponging microRNA-122-5p, thereby upregulating ADAM10.
    • However, the study has been retracted due to identified flaws and inconsistencies in experimental methods and results.

    Impact:

    • The conclusions drawn from the original study regarding LINC01551's role in HCC are now considered invalid.
    • This retraction highlights the importance of rigorous validation in scientific research and impacts the understanding of HCC pathogenesis.

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