Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Swiss army knife for the treatment of bone cancers: a new multifunctional platform based upon SPIONs@copper-doped bioactive glass core-shell nanoparticles.

Nanoscale·2026

Same author

Impact of volcanic emissions on the air quality during the 2021 volcanic eruption of Tajogaite, La Palma: Implications for population exposure to volcanic pollutants.

The Science of the total environment·2026

Same author

Submarine ash megabed fed by far-traveled, shoreline-crossing pyroclastic currents from a large explosive volcanic eruption.

Science advances·2025

Same author

Triggered by light and magnetism: smart foam PLLA/HAP/Fe<sub>3</sub>O<sub>4</sub> scaffolds for heat-controlled biomedical applications.

Journal of materials chemistry. B·2025

Same author

Novel Honeycomb Nanoclay Frameworks With Hemostatic and Antibacterial Properties.

Journal of biomedical materials research. Part B, Applied biomaterials·2024

Same author

Correlating the Effect of Composition and Textural Properties on Bioactivity for Pristine and Copper-Doped Binary Mesoporous Bioactive Glass Nanoparticles.

Materials (Basel, Switzerland)·2023

Search research articles

Related Experiment Video

Updated: Oct 27, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Tranexamic acid-loaded hemostatic nanoclay microsphere frameworks.

Isabelle Denry^1,2,3, Jean-Marie Nédélec³, Julie A Holloway²

¹Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, Iowa, USA.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

|July 21, 2021

Summary

Newly developed nanoclay microsphere frameworks loaded with tranexamic acid enhance hemostasis. These novel hemostatic agents improve clot structure and stiffness, offering potential for advanced hemorrhage control.

Keywords:

clotting time hemostasis nanoclay topical hemostatic agent tranexamic acid

More Related Videos

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Oct 27, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Area of Science:

Biomaterials Science
Hemostasis and Thrombosis Research
Nanotechnology Applications

Background:

Effective hemorrhage control relies on fast-acting topical hemostatic agents.
Retarding fibrinolysis is crucial for enhancing coagulation and improving survival rates.

Purpose of the Study:

To investigate the physical properties, loading capacity, and hemostatic efficacy of novel nanoclay microsphere frameworks (NMFs).
To evaluate NMFs loaded with tranexamic acid (TA) as an antifibrinolytic agent for improved hemostasis.

Main Methods:

Preparation of nanoclay compositions with varying levels of tranexamic acid (TA).
Assessment of TA incorporation and release from the nanoclay structure.
Evaluation of hemostatic properties, including activated partial thromboplastin time and clot stiffness.

Main Results:

Successful incorporation and ethanol-induced release of TA from the nanoclay structure.
Both TA-loaded and undoped NMFs significantly reduced activated partial thromboplastin time.
NMFs demonstrated increased clot stiffness, attributed to thinner fibrin fibers and denser clot structure.

Conclusions:

Newly developed nanoclay microsphere frameworks effectively incorporate and release tranexamic acid.
NMFs show significant potential as topical hemostatic agents by enhancing clot structure and reducing fibrinolysis.