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Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...

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Updated: Oct 27, 2025

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

Published on: June 22, 2013

Brain vulnerability and viability after ischaemia.

Stefano G Daniele^1,2,3, Georg Trummer⁴, Konstantin A Hossmann⁵

¹Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.

Nature Reviews. Neuroscience

|July 22, 2021

Summary

This summary is machine-generated.

The brain

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Area of Science:

Neuroscience
Cell Biology
Physiology

Background:

Brain's vulnerability to ischemic injury.
Questioning temporal limits of brain tolerance to circulatory arrest.

Purpose of the Study:

Assess cell type-specific mechanisms of global cerebral ischemia.
Examine conditions for heightened brain resilience.
Propose a multimodal framework for brain resuscitation.

Main Methods:

Review of existing studies (dissociated cells, tissue, organs, whole bodies).
Analysis of cell type-specific responses to ischemia.
Exploration of emerging technologies and experimental concepts.

Main Results:

Identified cell type-specific mechanisms of global cerebral ischemia.
Highlighted circumstances of increased brain resilience to injury.
Suggested strategies for translational research in cytoprotective therapies.

Conclusions:

Brain tolerance to circulatory arrest is more complex than previously thought.
Further research can lead to novel cytoprotective therapies.
A multimodal framework is proposed for investigating brain resuscitation.