Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

977
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
977
Plasticity00:58

Plasticity

2.6K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
2.6K
Brain Imaging01:14

Brain Imaging

421
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
421
Long-term Depression01:03

Long-term Depression

2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.7K
Long-term Depression01:05

Long-term Depression

32.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain.

PLoS biology·2025
Same author

A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit.

eLife·2024
Same author

Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.

eLife·2021
Same author

Adult Neurogenesis in the <i>Drosophila</i> Brain: The Evidence and the Void.

International journal of molecular sciences·2020
Same author

A Toll-receptor map underlies structural brain plasticity.

eLife·2020
Same author

Toll and Toll-like receptor signalling in development.

Development (Cambridge, England)·2018

Related Experiment Video

Updated: Oct 27, 2025

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

7.0K

The Toll Route to Structural Brain Plasticity.

Guiyi Li1, Alicia Hidalgo1

  • 1Plasticity and Regeneration Lab, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.

Frontiers in Physiology
|July 22, 2021
PubMed
Summary

Fruit flies reveal how Toll receptors regulate brain structural plasticity. This discovery in *Drosophila* may offer insights into human brain plasticity, degeneration, and disease.

Keywords:
DrosophilaTLRTolladult neurogenesishomeostasisneurodegenerationneurotrophinstructural brain plasticity

More Related Videos

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.3K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.3K

Related Experiment Videos

Last Updated: Oct 27, 2025

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

7.0K
Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.3K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.3K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • The adult brain exhibits structural plasticity, a balance crucial for healthy function, which is disrupted in various neurological and psychiatric disorders.
  • Understanding the molecular mechanisms underlying brain plasticity is essential for addressing conditions like neurodegenerative diseases and psychiatric disorders.
  • The fruit fly, *Drosophila*, serves as a powerful model organism for investigating the molecular basis of brain plasticity *in vivo*.

Purpose of the Study:

  • To explore the role of Toll receptors in regulating structural plasticity in the *Drosophila* central nervous system.
  • To investigate how Toll receptors mediate the translation of experience into structural brain changes.
  • To identify potential conserved mechanisms between *Drosophila* Toll receptors and mammalian Toll-like receptors in brain plasticity and disease.

Main Methods:

  • Review of existing literature on brain plasticity in *Drosophila*.
  • Analysis of the function and distribution of Toll receptors in the *Drosophila* brain.
  • Examination of Toll receptor signaling pathways and their impact on structural plasticity during development and in adulthood.

Main Results:

  • Toll receptors in the *Drosophila* central nervous system regulate structural plasticity throughout development and in the adult brain.
  • The topographic distribution and signaling flexibility of Tolls enable the brain to adapt structurally in response to experience.
  • Evidence suggests Toll receptors are key molecular mediators of experience-dependent structural brain changes.

Conclusions:

  • Toll receptors are critical regulators of structural brain plasticity in *Drosophila*, linking molecular mechanisms to functional adaptation.
  • The findings in *Drosophila* provide a foundation for exploring the role of Toll and Toll-like receptors in human brain plasticity and associated diseases.
  • Further research into Toll receptor function may uncover novel therapeutic targets for neurological and psychiatric conditions.