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Intestinal fat malabsorption in the uremic rat.

D Schurr1, E Levy, R Goldstein

  • 1Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel.

The International Journal of Pediatric Nephrology
|July 1, 1987
PubMed
Summary
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This study demonstrates that uremia impairs fat absorption in rats, confirming findings in chronic renal failure patients. This malabsorption is linked to impaired chylomicron appearance and triglyceride levels.

Area of Science:

  • Nephrology
  • Gastroenterology
  • Biochemistry

Background:

  • Patients with chronic renal failure (CRF) undergoing hemodialysis exhibit intestinal fat malabsorption.
  • An animal model is needed to further investigate the mechanisms behind this malabsorption.

Purpose of the Study:

  • To verify intestinal fat malabsorption in an animal model of chronic renal failure (CRF).
  • To assess the impact of uremia on fat absorption and triglyceride metabolism.

Main Methods:

  • Uremia was induced in male rats via subtotal nephrectomy (5/6).
  • Oral fat loading tests with Intralipid were performed.
  • Chylomicron appearance and serum triglyceride levels were monitored.
  • Hepatic triglyceride synthesis and lipoprotein lipase activity were manipulated using orotic acid and triton to isolate fat absorption effects.

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Main Results:

  • Chylomicron absorption was significantly impaired (p < 0.01) in uremic rats compared to controls.
  • Serum triglyceride rise was comparable in mildly uremic and control animals.
  • In severely uremic rats, the triglyceride rise was significantly blunted (p < 0.01) after fat loading, even with interventions to normalize synthesis and lipolysis.

Conclusions:

  • Uremia significantly impairs intestinal fat absorption, as evidenced by reduced chylomicron appearance.
  • The severity of fat malabsorption correlates with the degree of uremia.
  • These findings in an animal model support the clinical observations of fat malabsorption in patients with chronic renal failure.