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[Lambert-Eaton myasthenic syndrome].

M A Hernández1, A A Köhler1, M Marrodán1

  • 1Instituto de Investigaciones Neurológicas Dr. Raúl Carrea (FLENI), Buenos Aires, Argentina.

Revista De Neurologia
|July 22, 2021
PubMed
Summary
This summary is machine-generated.

This study on Lambert-Eaton myasthenic syndrome (LEMS) in Argentina found that clinical and neurophysiological findings are key for diagnosis. Pyridostigmine effectively treated symptoms in most patients.

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Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Lambert-Eaton myasthenic syndrome (LEMS) diagnosis relies on clinical signs, neurophysiology, and antibody titers for early treatment and cancer screening.
  • Published reports on LEMS patients in Latin America are limited.

Purpose of the Study:

  • To characterize LEMS patients from a private center in Buenos Aires, Argentina.
  • To compare these characteristics with previously published LEMS case series.

Main Methods:

  • Retrospective review of 13 LEMS patients' medical records.
  • Diagnosis confirmed by clinical findings, electromyography, and/or positive antibodies.
  • Follow-up to rule out or confirm associated neoplasia.

Main Results:

  • Four patients had tumor-associated LEMS (T-LEMS), with two diagnosed with small-cell lung carcinoma.
  • Nine patients had non-tumor-associated LEMS (NT-LEMS); five had a DELTA-P score of 3 or 4.
  • Nine patients presented with the classic LEMS triad; all showed compatible electromyography findings.
  • Symptomatic improvement with pyridostigmine was observed in 70% of patients.

Conclusions:

  • Clinical presentation and neurophysiological studies are adequate for LEMS diagnosis.
  • The study could not replicate the link between DELTA-P score and small-cell lung carcinoma risk.
  • Pyridostigmine is an effective symptomatic treatment for LEMS.